Measurement of cyclooxygenase inhibition using liquid chromatography-tandem mass spectrometry

Because cyclooxygenases (COX) convert arachidonic acid into pro-inflammatory cyclic endoperoxides, inhibition of these enzymes and especially the inducible COX-2 form is an important therapeutic approach to manage inflammatory diseases and possibly prevent cancer. Due to side effects of existing non...

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Bibliographic Details
Main Authors: Cao, Hongmei, Yu, Rui, Tao, Yi, Nikolic, Dejan, van Breemen, Richard B.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946453/
https://ncbi.nlm.nih.gov/pubmed/20817448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2010.08.001
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