Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway

BACKGROUND: Differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces cell differentiation in Dictyostelium discoideum. DIF-1 inhibits proliferation of various mammalian tumor cells by suppressing the canonical Wnt/β-catenin signaling pathway. To assess the potential of a novel...

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Hlavní autoři: Yoshihara, Tatsuya, Takahashi-Yanaga, Fumi, Shiraishi, Fumie, Morimoto, Sachio, Watanabe, Yutaka, Hirata, Masato, Hoka, Sumio, Sasaguri, Toshiyuki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946290/
https://ncbi.nlm.nih.gov/pubmed/20843378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-245
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