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Very High Affinity DNA Recognition by Bicyclic and Cross-Linked Oligonucleotides
We report the synthesis and DNA incorporation of a novel C-5 thiopropyne-substituted thymidine derivative which can be used to bring about covalent crosslinks between two noncomplementary DNA strands. This modified thymine pairs normally with adenine in duplex DNA and is shown not to be destabilizin...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1995
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2946160/ https://ncbi.nlm.nih.gov/pubmed/20882118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja00147a004 |
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