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Very High Affinity DNA Recognition by Bicyclic and Cross-Linked Oligonucleotides

We report the synthesis and DNA incorporation of a novel C-5 thiopropyne-substituted thymidine derivative which can be used to bring about covalent crosslinks between two noncomplementary DNA strands. This modified thymine pairs normally with adenine in duplex DNA and is shown not to be destabilizin...

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Detalhes bibliográficos
Main Authors: Chaudhuri, Narayan C., Kool, Eric T.
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946160/
https://ncbi.nlm.nih.gov/pubmed/20882118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja00147a004
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