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Smad7 Inhibits Transforming Growth Factor-β Family Type I Receptors through Two Distinct Modes of Interaction

The inhibitory Smads (I-Smads), i.e. Smad6 and Smad7, are negative regulators of transforming growth factor-β (TGF-β) family signaling. I-Smads inhibit TGF-β family signaling principally through physical interaction with type I receptors (activin receptor-like kinases), so as to compete with recepto...

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Détails bibliographiques
Auteurs principaux: Kamiya, Yuto, Miyazono, Kohei, Miyazawa, Keiji
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945574/
https://ncbi.nlm.nih.gov/pubmed/20663871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.166140
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