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Hrs Controls Sorting of the Epithelial Na(+) Channel between Endosomal Degradation and Recycling Pathways
Epithelial Na(+) absorption is regulated by Nedd4-2, an E3 ubiquitin ligase that reduces expression of the epithelial Na(+) channel (ENaC) at the cell surface. Defects in this regulation cause Liddle syndrome, an inherited form of hypertension. Previous work found that Nedd4-2 functions through two...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945546/ https://ncbi.nlm.nih.gov/pubmed/20675381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150755 |
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