Pleiotropic Effects of p300-mediated Acetylation on p68 and p72 RNA Helicase

Here, we demonstrate that p68 (DDX5) and p72 (DDX17), two homologous RNA helicases and transcriptional cofactors, are substrates for the acetyltransferase p300 in vitro and in vivo. Mutation of acetylation sites affected the binding of p68/p72 to histone deacetylases, but not to p300 or estrogen rec...

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Hlavní autoři: Mooney, Steven M., Goel, Apollina, D'Assoro, Antonino B., Salisbury, Jeffrey L., Janknecht, Ralf
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945537/
https://ncbi.nlm.nih.gov/pubmed/20663877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.143792
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