Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium.

Excess alpha-ketobutyrate inhibited the growth of Salmonella typhimurium LT2 by inhibiting the acetohydroxy acid synthase-catalyzed synthesis of alpha-acetolactate (a valine precursor). As a result, cells were starved for valine, and both ilvB (encoding acetohydroxy acid synthase I) and ilvGEDA (ilv...

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Pubblicato in:	J Bacteriol
Autori principali:	Shaw, K J, Berg, C M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294547/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6997277/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.143.3.1509-1512.1980
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