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Substrate channeling: alpha-ketobutyrate inhibition of acetohydroxy acid synthase in Salmonella typhimurium.

Excess alpha-ketobutyrate inhibited the growth of Salmonella typhimurium LT2 by inhibiting the acetohydroxy acid synthase-catalyzed synthesis of alpha-acetolactate (a valine precursor). As a result, cells were starved for valine, and both ilvB (encoding acetohydroxy acid synthase I) and ilvGEDA (ilv...

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Bibliografski detalji
Glavni autori: Shaw, K J, Berg, C M
Format: Artigo
Jezik:Inglês
Izdano: 1980
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC294547/
https://ncbi.nlm.nih.gov/pubmed/6997277
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