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IL-24 Gene Transfer Sensitizes Melanoma Cells to Erlotinib through Modulation of the Apaf-1 and Akt Signaling Pathways
IL-24 is a novel tumor suppressor/cytokine gene expressed in normal human melanocytes but for which expression is nearly undetectable in metastatic melanoma. Overexpression of IL-24 protein has been shown to inhibit tumor cell proliferation and induce apoptosis in many melanoma cell lines, and is no...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945428/ https://ncbi.nlm.nih.gov/pubmed/20216471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CMR.0b013e3283382155 |
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