Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

BACKGROUND: In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG). Recent evidence strongly suggests that AQP4-Ab are directly involved in the immunopathogenesis of NMO. OBJECTIVE: To assess the frequency, s...

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Main Authors: Jarius, Sven, Franciotta, Diego, Paul, Friedemann, Ruprecht, Klemens, Bergamaschi, Roberto, Rommer, Paulus S, Reuss, Reinhard, Probst, Christian, Kristoferitsch, Wolfgang, Wandinger, Klaus Peter, Wildemann, Brigitte
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945323/
https://ncbi.nlm.nih.gov/pubmed/20825655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-7-52
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