Lung Vascular Targeting Using Antibody to Aminopeptidase P: CT-SPECT Imaging, Biodistribution and Pharmacokinetic Analysis

BACKGROUND/AIMS: Aminopeptidase P (APP) is specifically enriched in caveolae on the luminal surface of pulmonary vascular endothelium. APP antibodies bind lung endothelium in vivo and are rapidly and actively pumped across the endothelium into lung tissue. Here we characterize the immunotargeting pr...

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Bibliografiset tiedot
Päätekijät: Chrastina, A., Valadon, P., Massey, K.A., Schnitzer, J.E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: S. Karger AG 2010
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945271/
https://ncbi.nlm.nih.gov/pubmed/20431301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000313880
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