Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain

INTRODUCTION: The Vβ12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) β-chain and cons...

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Bibliographic Details
Main Authors: Merky, Patrick, Batsalova, Tsvetelina, Bockermann, Robert, Dzhambazov, Balik, Sehnert, Bettina, Burkhardt, Harald, Bäcklund, Johan
Format: Artigo
Language:Inglês
Published: BioMed Central 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945055/
https://ncbi.nlm.nih.gov/pubmed/20682070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3108
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