Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties.

We have tested the hypothesis that oxidation of lung surfactant results in loss of surface tension lowering function. Porcine lung surfactant was exposed to conditions known to cause lipid peroxidation (0.2 mM FeCl2 + 0.1 mM H2O2 or 5 microM CuCl2). Lipid peroxidation was verified by detection of co...

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Pubblicato in:	J Clin Invest
Autori principali:	Gilliard, N, Heldt, G P, Loredo, J, Gasser, H, Redl, H, Merritt, T A, Spragg, R G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8200999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117273
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