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Loss of Maternal ATRX Results in Centromere Instability and Aneuploidy in the Mammalian Oocyte and Pre-Implantation Embryo

The α-thalassemia/mental retardation X-linked protein (ATRX) is a chromatin-remodeling factor known to regulate DNA methylation at repetitive sequences of the human genome. We have previously demonstrated that ATRX binds to pericentric heterochromatin domains in mouse oocytes at the metaphase II sta...

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書誌詳細
主要な著者: Baumann, Claudia, Viveiros, Maria M., De La Fuente, Rabindranath
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944790/
https://ncbi.nlm.nih.gov/pubmed/20885787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001137
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