Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt, having point mutations that associate completely with CQR in parasite lines from Asia, Africa, and South...

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Hauptverfasser: Fidock, David A., Nomura, Takashi, Talley, Angela K., Cooper, Roland A., Dzekunov, Sergey M., Ferdig, Michael T., Ursos, Lyann M. B., Sidhu, Amar bir Singh, Naudé, Bronwen, Deitsch, Kirk W., Su, Xin-zhuan, Wootton, John C., Roepe, Paul D., Wellems, Thomas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944663/
https://ncbi.nlm.nih.gov/pubmed/11090624
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