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Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes.

Levels of insulin autoantibodies (IAA) vary among different first degree relatives of insulin-dependent diabetes mellitus patients, suggesting genetic regulation. We previously reported elevated IAA among DR4-positive at risk relatives. In this study, 72/82 at risk relatives were IAA positive, of wh...

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Detalhes bibliográficos
Main Authors: Pugliese, A, Bugawan, T, Moromisato, R, Awdeh, Z L, Alper, C A, Jackson, R A, Erlich, H A, Eisenbarth, G S
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC294453/
https://ncbi.nlm.nih.gov/pubmed/8200980
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