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Upregulation of Na(+)/Ca(2+) exchanger and TRPC6 contributes to abnormal Ca(2+) homeostasis in arterial smooth muscle cells from Milan hypertensive rats

The Milan hypertensive strain (MHS) of rats is a model for hypertension in humans. Inherited defects in renal function have been well studied in MHS rats, but the mechanisms that underlie the elevated vascular resistance are unclear. Altered Ca(2+) signaling plays a key role in the vascular dysfunct...

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Autors principals: Zulian, Alessandra, Baryshnikov, Sergey G., Linde, Cristina I., Hamlyn, John M., Ferrari, Patrizia, Golovina, Vera A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944478/
https://ncbi.nlm.nih.gov/pubmed/20622104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00356.2010
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