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Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue
Sphingomyelinase (SMase) hydrolyzes membrane sphingomyelin into ceramide, which increases oxidants in nonmuscle cells. Serum SMase activity is elevated in sepsis and heart failure, conditions where muscle oxidants are increased, maximal muscle force is diminished, and fatigue is accelerated. We test...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944322/ https://ncbi.nlm.nih.gov/pubmed/20519448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00065.2010 |
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