CXCL12 Chemokine Expression and Secretion Regulates Colorectal Carcinoma Cell Anoikis through Bim-Mediated Intrinsic Apoptosis

BACKGROUND: Resistance to anoikis, apoptosis triggered by a loss of cellular adhesion to the underlying extracellular matrix, is a hallmark of metastatic cancer. Previously we have shown re-establishment of CXCL12 expression in colorectal carcinoma cells inhibits metastasis by enhancing anoikis sens...

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Bibliografiska uppgifter
Huvudupphovsmän: Drury, Luke J., Wendt, Michael K., Dwinell, Michael B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943927/
https://ncbi.nlm.nih.gov/pubmed/20877573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012895
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