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Delayed Activation of p63/p53/p19/Apoptosis Increased Sensitivity of NQO1 and NQO2 deficient Mice to Benzo(a)pyrene and Dimethylbenz(a)anthracene Induced Skin Tumors
Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that detoxify quinones, prevent redox cycling and protect cells against oxidative stress and neoplasia. Double knockout (DKO) mice deficient in both NQO1 and NQO2 proteins were generated in our laboratory. To investigate the combined rol...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2943744/ https://ncbi.nlm.nih.gov/pubmed/20103645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2938 |
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