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Confinement-Optimized 3-Dimensional T cell Amoeboid Motility is Modulated via Myosin IIA-Regulated Adhesions

During trafficking through tissues, T cells fine-tune their motility to balance the extent and duration of cell-surface contacts with the need to traverse an entire organ. In vivo, Myosin-IIA-deficient T cells exhibited a triad of defects including over-adherence to high-endothelial venules, reduced...

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Bibliographische Detailangaben
Hauptverfasser: Jacobelli, Jordan, Friedman, Rachel S., Conti, Mary Anne, Lennon-Dumenil, Ana-Maria, Piel, Matthieu, Sorensen, Caitlin M., Adelstein, Robert S., Krummel, Matthew F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943564/
https://ncbi.nlm.nih.gov/pubmed/20835229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1936
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