Cocaine-Induced Chromatin Remodeling Increases Brain-Derived Neurotrophic Factor Transcription in the Rat Medial Prefrontal Cortex, Which Alters the Reinforcing Efficacy of Cocaine

Cocaine self-administration alters patterns of gene expression in the brain that may underlie cocaine-induced neuronal plasticity. In the present study, male Sprague Dawley rats were allowed to self-administer cocaine (0.25 mg/infusion) 2 h/d for 14 d, followed by 7 d of forced abstinence. Compared...

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Main Authors: Sadri-Vakili, Ghazaleh, Kumaresan, Vidhya, Schmidt, Heath D., Famous, Katie R., Chawla, Prianka, Vassoler, Fair M., Overland, Ryan P., Xia, Eva, Bass, Caroline E., Terwilliger, Ernest F., Pierce, R. Christopher, Cha, Jang-Ho J.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943400/
https://ncbi.nlm.nih.gov/pubmed/20810894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2328-10.2010
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