Study of the Individual Cytochrome b(5) and Cytochrome b(5) Reductase Domains of Ncb5or Reveals a Unique Heme Pocket and a Possible Role of the CS Domain

NADH cytochrome b(5) oxidoreductase (Ncb5or) is found in animals and contains three domains similar to cytochrome b(5) (b(5)), CHORD-SGT1 (CS), and cytochrome b(5) reductase (b(5)R). Ncb5or has an important function, as suggested by the diabetes and lipoatrophy phenotypes in Ncb5or null mice. To elu...

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Bibliographic Details
Main Authors: Deng, Bin, Parthasarathy, Sudharsan, Wang, WenFang, Gibney, Brian R., Battaile, Kevin P., Lovell, Scott, Benson, David R., Zhu, Hao
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943328/
https://ncbi.nlm.nih.gov/pubmed/20630863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.120329
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