Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals

OBJECTIVE: To illustrate the utility of statistical monitoring boundaries in meta-analysis, and provide a framework in which meta-analysis can be interpreted according to the adequacy of sample size. To propose a simple method for determining how many patients need to be randomized in a future trial...

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Bibliographic Details
Main Authors: Thorlund, Kristian, Anema, Aranka, Mills, Edward
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2010
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943189/
https://ncbi.nlm.nih.gov/pubmed/20865104
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