Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene.

Brain natriuretic peptide (BNP) is a cardiac hormone that occurs predominantly in the ventricle. To study the roles of BNP in chronic cardiovascular regulation, we isolated mouse BNP cDNA and genomic clones, and generated transgenic mice with elevated plasma BNP concentration. The mouse BNP gene was...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Invest
Hauptverfasser: Ogawa, Y, Itoh, H, Tamura, N, Suga, S, Yoshimasa, T, Uehira, M, Matsuda, S, Shiono, S, Nishimoto, H, Nakao, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1994
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294298/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8182124/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117182
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