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Phosphorylation of GIT1 tyrosine-392 is required for PLCγ activation and podosome formation in vascular smooth muscle cells

OBJECTIVE: Podosomes, actin-rich structures, contribute to cell motility, matrix remodeling and tissue remodeling. We have shown that G-protein coupled receptor kinase 2-interacting protein 1 (GIT1) co-localizes with podosomes, and is important in podosome formation in endothelial cells. Src stimula...

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Detalhes bibliográficos
Main Authors: Wang, Jing, Yin, Guoyong, Menon, Prashanthi, Pang, Jinjiang, Smolock, Elaine M, Yan, Chen, Berk, Bradford C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941990/
https://ncbi.nlm.nih.gov/pubmed/20689073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.212415
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