Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by loss of motor neurons. With conformation specific antibodies, we now demonstrate that misfolded mutant SOD1 binds directly to the voltage-dependent anion channel (VDAC1),...

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主要な著者: Israelson, Adrian, Arbel, Nir, Cruz, Sandrine Da, Ilieva, Hristelina, Yamanaka, Koji, Shoshan-Barmatz, Varda, Cleveland, Don W.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941987/
https://ncbi.nlm.nih.gov/pubmed/20797535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.07.019
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