Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2.

Production of leukotriene B4 (LTB4) by human neutrophils (PMN) in response to different stimuli is increased after pretreatment with lipopolysaccharides (LPS). We have analyzed the steps in arachidonic acid (AA) metabolism affected by LPS by examining release of AA and its metabolites from [3H]AA pr...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Doerfler, M E, Weiss, J, Clark, J D, Elsbach, P
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294185/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512985/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117138
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