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Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation
4-Hydroxyequilenin (4-OHEN) is a major phase I metabolite of the equine estrogens present in widely prescribed hormone replacement formulations. 4-OHEN is autoxidized to an electrophilic o-quinone that has been shown to redox cycle, generating ROS, and to covalently modify proteins and DNA and thus...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941764/ https://ncbi.nlm.nih.gov/pubmed/20540524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100129h |
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