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Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation

4-Hydroxyequilenin (4-OHEN) is a major phase I metabolite of the equine estrogens present in widely prescribed hormone replacement formulations. 4-OHEN is autoxidized to an electrophilic o-quinone that has been shown to redox cycle, generating ROS, and to covalently modify proteins and DNA and thus...

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Detalhes bibliográficos
Main Authors: Peng, Kuan-Wei, Chang, Minsun, Wang, Yue-Ting, Wang, Zhican, Qin, Zhihui, Bolton, Judy L., Thatcher, Gregory R. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941764/
https://ncbi.nlm.nih.gov/pubmed/20540524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100129h
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