Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II-peptide complexes.

In autoimmune disorders, inactivation of pathogenic antigen-specific T cells, rather than global immunosuppression, would be highly desirable. One way to achieve this would be to deliver the first antigen-specific signal to the T cell in the absence of the second costimulatory signal. Myasthenia gra...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Nicolle, M W, Nag, B, Sharma, S D, Willcox, N, Vincent, A, Ferguson, D J, Newsom-Davis, J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294148/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7512979/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117112
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