Degradation of p53 by Human Alphapapillomavirus E6 Proteins Shows a Stronger Correlation with Phylogeny than Oncogenicity

BACKGROUND: Human Papillomavirus (HPV) E6 induced p53 degradation is thought to be an essential activity by which high-risk human Alphapapillomaviruses (alpha-HPVs) contribute to cervical cancer development. However, most of our understanding is derived from the comparison of HPV16 and HPV11. These...

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Bibliographic Details
Main Authors: Fu, Leiping, Van Doorslaer, Koenraad, Chen, Zigui, Ristriani, Tutik, Masson, Murielle, Travé, Gilles, Burk, Robert D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941455/
https://ncbi.nlm.nih.gov/pubmed/20862247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012816
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