Transduction of Brain Dopamine Neurons by Adenoviral Vectors Is Modulated by CAR Expression: Rationale for Tropism Modified Vectors in PD Gene Therapy

BACKGROUND: Gene-based therapy is a new paradigm for the treatment of Parkinson disease (PD) and offers considerable promise for precise targeting and flexibility to impact multiple pathobiological processes for which small molecule agents are not available. Some success has been achieved utilizing...

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Bibliographic Details
Main Authors: Lewis, Travis B., Glasgow, Joel N., Glandon, Anya M., Curiel, David T., Standaert, David G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941453/
https://ncbi.nlm.nih.gov/pubmed/20862245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012672
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