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Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations()

Neural network breakdown is a key issue in neurodegenerative disease, but the mechanisms are poorly understood. Here we investigated patterns of brain atrophy produced by defined molecular lesions in the two common forms of genetically mediated frontotemporal lobar degeneration (FTLD). Nine patients...

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Hlavní autoři: Rohrer, Jonathan D., Ridgway, Gerard R., Modat, Marc, Ourselin, Sebastien, Mead, Simon, Fox, Nick C., Rossor, Martin N., Warren, Jason D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Academic Press 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941039/
https://ncbi.nlm.nih.gov/pubmed/20045477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2009.12.088
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