ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma(†)

Vestibular schwannomas (VS) arising sporadically or in patients with neurofibromatosis type 2 (NF2) consistently lack expression of Merlin, a tumor suppressor. Conventional treatment options include surgery and radiotherapy but there is no validated medical option. Recent evidence suggests that Merl...

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Hlavní autoři: Ammoun, Sylwia, Cunliffe, Clare H., Allen, Jeffrey C., Chiriboga, Luis, Giancotti, Filippo G., Zagzag, David, Hanemann, C. Oliver, Karajannis, Matthias A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940674/
https://ncbi.nlm.nih.gov/pubmed/20511180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq012
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