Biochemical Correction of Short-Chain Acyl-Coenzyme A Dehydrogenase Deficiency After Portal Vein Injection of rAAV8-SCAD

Recombinant adeno-associated viral vectors pseudotyped with serotype 5 and 8 capsids (AAV5 and AAV8) have been shown to be efficient gene transfer reagents for the liver. We have produced AAV5 and AAV8 vectors that express mouse short-chain acyl-CoA dehydrogenase (mSCAD) cDNA under the transcription...

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Detalhes bibliográficos
Main Authors: Beattie, Stuart G., Goetzman, Eric, Conlon, Thomas, Germain, Sean, Walter, Glenn, Campbell-Thompson, Martha, Matern, Dietrich, Vockley, Jerry, Flotte, Terence R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2008
Assuntos:
Scientific Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940548/
https://ncbi.nlm.nih.gov/pubmed/18500942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2007.168
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