Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection

BACKGROUND: Although chronic liver disease is associated with gastroesophageal reflux disease (GERD), the impact of chronic hepatitis B virus (HBV) infection on this association remains unclear. We thus aimed to evaluate the relationship between chronic HBV infection and GERD. METHODS: In this prosp...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Hsu, Ching-Sheng, Wang, Chia-Chi, Wang, Pin-Chao, Lin, Hans Hsienhong, Tseng, Tai-Chung, Chen, Chien-Hwa, Su, Wei-Chih, Liu, Chun-Jen, Chen, Chi-Ling, Lai, Ming-Yang, Chen, Pei-Jer, Chen, Ding-Shinn, Kao, Jia-Horng
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer-Verlag 2010
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940010/
https://ncbi.nlm.nih.gov/pubmed/21063481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-010-9184-4
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
id pubmed-2940010
record_format dspace
spelling pubmed-29400102010-11-09 Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection Hsu, Ching-Sheng Wang, Chia-Chi Wang, Pin-Chao Lin, Hans Hsienhong Tseng, Tai-Chung Chen, Chien-Hwa Su, Wei-Chih Liu, Chun-Jen Chen, Chi-Ling Lai, Ming-Yang Chen, Pei-Jer Chen, Ding-Shinn Kao, Jia-Horng Hepatol Int Original Article BACKGROUND: Although chronic liver disease is associated with gastroesophageal reflux disease (GERD), the impact of chronic hepatitis B virus (HBV) infection on this association remains unclear. We thus aimed to evaluate the relationship between chronic HBV infection and GERD. METHODS: In this prospective population-based study, 1,001 adult subjects who underwent an upper gastrointestinal endoscopic examination in a health check-up and completed a gastroesophageal reflux questionnaire were consecutively enrolled. Endoscopic findings were classified according to the Los Angeles classification. Hepatitis B surface antigen was used as a marker of HBV infection. Univariate and multivariate approaches were used to evaluate the effects of chronic HBV infection on GERD. RESULTS: Chronic HBV infection was associated with heartburn sensation [odds ratio (OR) 1.27, 95% confidence interval 1.01–1.61, P = 0.037], and erosive esophagitis (adjusted OR 1.75, 1.03–2.97, P = 0.037). Although male gender is a risk factor of erosive esophagitis, further analyses stratified by gender and aspartate aminotransferase to platelet ratio index (APRI) showed that chronic HBV infection was associated with erosive esophagitis in female subjects (adjusted OR 2.70, 1.14–6.39, P = 0.024) and those with APRI of more than 0.3 (adjusted OR 3.94, 1.73–8.96, P = 0.001). Moreover, higher serum aspartate aminotransferase (AST) and triglyceride (TG) levels were risk factors of erosive esophagitis in patients with chronic HBV infection. CONCLUSIONS: Our findings indicate a close association between chronic HBV infection and GERD, especially in female subjects and those with higher APRI levels. Moreover, HBV carriers with higher AST or TG levels have higher incidence of erosive esophagitis. The interactions between chronic HBV infection and GERD need further studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12072-010-9184-4) contains supplementary material, which is available to authorized users. Springer-Verlag 2010-07-01 /pmc/articles/PMC2940010/ /pubmed/21063481 http://dx.doi.org/10.1007/s12072-010-9184-4 Text en © Asian Pacific Association for the Study of the Liver 2010
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Original Article
spellingShingle Original Article
Hsu, Ching-Sheng
Wang, Chia-Chi
Wang, Pin-Chao
Lin, Hans Hsienhong
Tseng, Tai-Chung
Chen, Chien-Hwa
Su, Wei-Chih
Liu, Chun-Jen
Chen, Chi-Ling
Lai, Ming-Yang
Chen, Pei-Jer
Chen, Ding-Shinn
Kao, Jia-Horng
Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection
description BACKGROUND: Although chronic liver disease is associated with gastroesophageal reflux disease (GERD), the impact of chronic hepatitis B virus (HBV) infection on this association remains unclear. We thus aimed to evaluate the relationship between chronic HBV infection and GERD. METHODS: In this prospective population-based study, 1,001 adult subjects who underwent an upper gastrointestinal endoscopic examination in a health check-up and completed a gastroesophageal reflux questionnaire were consecutively enrolled. Endoscopic findings were classified according to the Los Angeles classification. Hepatitis B surface antigen was used as a marker of HBV infection. Univariate and multivariate approaches were used to evaluate the effects of chronic HBV infection on GERD. RESULTS: Chronic HBV infection was associated with heartburn sensation [odds ratio (OR) 1.27, 95% confidence interval 1.01–1.61, P = 0.037], and erosive esophagitis (adjusted OR 1.75, 1.03–2.97, P = 0.037). Although male gender is a risk factor of erosive esophagitis, further analyses stratified by gender and aspartate aminotransferase to platelet ratio index (APRI) showed that chronic HBV infection was associated with erosive esophagitis in female subjects (adjusted OR 2.70, 1.14–6.39, P = 0.024) and those with APRI of more than 0.3 (adjusted OR 3.94, 1.73–8.96, P = 0.001). Moreover, higher serum aspartate aminotransferase (AST) and triglyceride (TG) levels were risk factors of erosive esophagitis in patients with chronic HBV infection. CONCLUSIONS: Our findings indicate a close association between chronic HBV infection and GERD, especially in female subjects and those with higher APRI levels. Moreover, HBV carriers with higher AST or TG levels have higher incidence of erosive esophagitis. The interactions between chronic HBV infection and GERD need further studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12072-010-9184-4) contains supplementary material, which is available to authorized users.
author Hsu, Ching-Sheng
Wang, Chia-Chi
Wang, Pin-Chao
Lin, Hans Hsienhong
Tseng, Tai-Chung
Chen, Chien-Hwa
Su, Wei-Chih
Liu, Chun-Jen
Chen, Chi-Ling
Lai, Ming-Yang
Chen, Pei-Jer
Chen, Ding-Shinn
Kao, Jia-Horng
author_facet Hsu, Ching-Sheng
Wang, Chia-Chi
Wang, Pin-Chao
Lin, Hans Hsienhong
Tseng, Tai-Chung
Chen, Chien-Hwa
Su, Wei-Chih
Liu, Chun-Jen
Chen, Chi-Ling
Lai, Ming-Yang
Chen, Pei-Jer
Chen, Ding-Shinn
Kao, Jia-Horng
author_sort Hsu, Ching-Sheng
title Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection
title_short Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection
title_full Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection
title_fullStr Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection
title_full_unstemmed Increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis B virus infection
title_sort increased incidence of gastroesophageal reflux disease in patients with chronic hepatitis b virus infection
publisher Springer-Verlag
publishDate 2010
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2940010/
https://ncbi.nlm.nih.gov/pubmed/21063481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12072-010-9184-4
_version_ 1753972611839164416

Samankaltaisia teoksia