TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

Extracellular and intracellular mediators of inflammation, such as Tumor Necrosis Factor alpha (TNFα) and NF-kappaB (NF-κB), play major roles in breast cancer pathogenesis, progression and relapse. SLUG, a mediator of the epithelial-mesenchymal transition process, is over-expressed in CD44(+)/CD24(−...

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Detalhes bibliográficos
Main Authors: Storci, Gianluca, Sansone, Pasquale, Mari, Sara, D’Uva, Gabriele, Tavolari, Simona, Guarnieri, Tiziana, Taffurelli, Mario, Ceccarelli, Claudio, Santini, Donatella, Chieco, Pasquale, Marcu, Kenneth B., Bonafè, Massimiliano
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939957/
https://ncbi.nlm.nih.gov/pubmed/20509143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.22264
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