Gene Delivery of Sarcoplasmic Reticulum Calcium ATPase Inhibits Ventricular Remodeling in Ischemic Mitral Regurgitation

BACKGROUND: Mitral regurgitation (MR) doubles mortality following myocardial infarction (MI). We have demonstrated that MR worsens remodeling after MI, and that early correction reverses remodeling. SERCA2a is downregulated in this process. We hypothesized that upregulating SERCA2a may inhibit remod...

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Hauptverfasser: Beeri, Ronen, Chaput, Miguel, Guerrero, J. Luis, Kawase, Yoshiaki, Yosefy, Chaim, Abedat, Suzan, Karakikes, Ioannis, Morel, Charlotte, Tisosky, Ashley, Sullivan, Suzanne, Handschumacher, Mark, Gilon, Dan, Vlahakes, Gus J., Hajjar, Roger J., Levine, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939951/
https://ncbi.nlm.nih.gov/pubmed/20634484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.891184
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