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Gene Delivery of Sarcoplasmic Reticulum Calcium ATPase Inhibits Ventricular Remodeling in Ischemic Mitral Regurgitation
BACKGROUND: Mitral regurgitation (MR) doubles mortality following myocardial infarction (MI). We have demonstrated that MR worsens remodeling after MI, and that early correction reverses remodeling. SERCA2a is downregulated in this process. We hypothesized that upregulating SERCA2a may inhibit remod...
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| 主要な著者: | , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939951/ https://ncbi.nlm.nih.gov/pubmed/20634484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.891184 |
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