Novel Photosensitizers Trigger Rapid Death of Malignant Human Cells and Rodent Tumor Transplants via Lipid Photodamage and Membrane Permeabilization

BACKGROUND: Apoptotic cascades may frequently be impaired in tumor cells; therefore, the approaches to circumvent these obstacles emerge as important therapeutic modalities. METHODOLOGY/PRINCIPAL FINDINGS: Our novel derivatives of chlorin e(6), that is, its amide (compound 2) and boronated amide (co...

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Main Authors: Moisenovich, Mikhail M., Ol'shevskaya, Valentina A., Rokitskaya, Tatyana I., Ramonova, Alla A., Nikitina, Roza G., Savchenko, Arina N., Tatarskiy, Victor V., Kaplan, Mikhail A., Kalinin, Valery N., Kotova, Elena A., Uvarov, Oleg V., Agapov, Igor I., Antonenko, Yuri N., Shtil, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939899/
https://ncbi.nlm.nih.gov/pubmed/20856679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012717
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