Fine-Mapping Resolves Eae23 into Two QTLs and Implicates ZEB1 as a Candidate Gene Regulating Experimental Neuroinflammation in Rat

BACKGROUND: To elucidate mechanisms involved in multiple sclerosis (MS), we studied genetic regulation of experimental autoimmune encephalomyelitis (EAE) in rats, assuming a conservation of pathogenic pathways. In this study, we focused on Eae23, originally identified to regulate EAE in a (LEW.1AV1x...

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Detalhes bibliográficos
Main Authors: Stridh, Pernilla, Thessen Hedreul, Melanie, Beyeen, Amennai Daniel, Adzemovic, Milena Z., Laaksonen, Hannes, Gillett, Alan, Öckinger, Johan, Marta, Monica, Lassmann, Hans, Becanovic, Kristina, Jagodic, Maja, Olsson, Tomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939884/
https://ncbi.nlm.nih.gov/pubmed/20856809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012716
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