Novel GLP-1 Fusion Chimera as Potent Long Acting GLP-1 Receptor Agonist

GLP-1 has a variety of anti-diabetic effects. However, native GLP-1 is not suitable for therapy of diabetes due to its short half-life (t1/2<2 min). To circumvent this, we developed a long-lasting GLP-1 receptor agonist by the fusion of GLP-1 with human IgG2 Fc (GLP-1/hIgG2). ELISA-based receptor...

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Bibliografische gegevens
Hoofdauteurs: Wang, Qinghua, Chen, Kui, Liu, Rui, Zhao, Fang, Gupta, Sandeep, Zhang, Nina, Prud'homme, Gerald J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2010
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939854/
https://ncbi.nlm.nih.gov/pubmed/20856794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012734
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