The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy

A systematic Drosophila forward genetic screen for photoreceptor synaptic transmission mutants identified no-on-and-no-off transient C (nonC) based on loss of retinal synaptic responses to light stimulation. The cloned gene encodes phosphatidylinositol-3-kinase-like kinase (PIKK) Smg1, a regulatory...

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Autores principales: Long, A. Ashleigh, Mahapatra, Cecon T., Woodruff, Elvin A., Rohrbough, Jeff, Leung, Hung-Tat, Shino, Shikoh, An, Lingling, Doerge, Rebecca W., Metzstein, Mark M., Pak, William L., Broadie, Kendal
Formato: Artigo
Lenguaje:Inglês
Publicado: Company of Biologists 2010
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939802/
https://ncbi.nlm.nih.gov/pubmed/20826458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.069468
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