Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients

BACKGROUND: It can be hypothesised that inherited polymorphisms in the drug-transporter ABCB1 gene may interfere with interindividual variations in drug response in breast cancer patients. Docetaxel is a substrate for ABCB1 whose function has been shown to be modulated by oestrogen and progesterone....

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Detalhes bibliográficos
Main Authors: Fajac, A, Gligorov, J, Rezai, K, Lévy, P, Lévy, E, Selle, F, Beerblock, K, Avenin, D, Saintigny, P, Hugonin, S, Bernaudin, J-F, Lokiec, F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939787/
https://ncbi.nlm.nih.gov/pubmed/20628376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605789
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