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Mechanistic modelling of dynamic MRI data predicts that tumour heterogeneity decreases therapeutic response

BACKGROUND: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) contains crucial information about tumour heterogeneity and the transport limitations that reduce drug efficacy. Mathematical modelling of drug delivery and cellular responsiveness based on underutilised DCE-MRI data has the...

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Detalhes bibliográficos
Main Authors: Venkatasubramanian, R, Arenas, R B, Henson, M A, Forbes, N S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939778/
https://ncbi.nlm.nih.gov/pubmed/20628390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605773
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