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Simultaneous Pharmacokinetics/Pharmacodynamics Modeling of Recombinant Human Erythropoietin upon Multiple Intravenous Dosing in Rats

A pharmacokinetics (PK)/pharmacodynamics (PD) model was developed to describe the tolerance and rebound for reticulocyte (RET) and red blood cell (RBC) counts and the hemoglobin (Hb) concentrations in blood after repeated intravenous administrations of 1350 IU/kg of recombinant human erythropoietin...

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Main Authors: Ait-Oudhia, Sihem, Scherrmann, Jean-Michel, Krzyzanski, Wojciech
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939674/
https://ncbi.nlm.nih.gov/pubmed/20501635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.167304
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