COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

BACKGROUND: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function...

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Main Authors: Veltman, Joris D, Lambers, Margaretha EH, van Nimwegen, Menno, Hendriks, Rudi W, Hoogsteden, Henk C, Aerts, Joachim GJV, Hegmans, Joost PJJ
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939552/
https://ncbi.nlm.nih.gov/pubmed/20804550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-464
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