A Novel Histone Deacetylase Inhibitor Exhibits Antitumor Activity via Apoptosis Induction, F-Actin Disruption and Gene Acetylation in Lung Cancer

BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide, yet the therapeutic strategy for advanced non-small cell lung cancer (NSCLC) is limitedly effective. In addition, validated histone deacetylase (HDAC) inhibitors for the treatment of solid tumors remain to be developed. Here...

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Main Authors: Tang, Yen-An, Wen, Wei-Ling, Chang, Jer-Wei, Wei, Tzi-Tang, Tan, Yi-Hung Carol, Salunke, Santosh, Chen, Chien-Tien, Chen, Ching-Shih, Wang, Yi-Ching
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939045/
https://ncbi.nlm.nih.gov/pubmed/20856855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012417
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