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MEK1(act)/tubulin interaction is an important determinant of mitotic stability in cultured HT1080 human fibrosarcoma cells
Activation of the MAPK pathway plays a major role in neoplastic cell transformation. Using a proteomics approach we identified α tubulin and β tubulin as proteins that interact with activated MEK1, a central MAPK regulatory kinase. Confocal analysis revealed spatio-temporal control of MEK1-tubulin c...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938962/ https://ncbi.nlm.nih.gov/pubmed/20570892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4490 |
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