Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

Mantle cell lymphoma (MCL) is a mostly incurable malignancy arising from naive B cells (NBCs) in the mantle zone of lymph nodes. We analyzed genomewide methylation in MCL patients with the HELP (HpaII tiny fragment Enrichment by Ligation–mediated PCR) assay and found significant aberrancy in promote...

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Detalhes bibliográficos
Main Authors: Leshchenko, Violetta V., Kuo, Pei-Yu, Shaknovich, Rita, Yang, David T., Gellen, Tobias, Petrich, Adam, Yu, Yiting, Remache, Yvonne, Weniger, Marc A., Rafiq, Sarwish, Suh, K. Stephen, Goy, Andre, Wilson, Wyndham, Verma, Amit, Braunschweig, Ira, Muthusamy, Natarajan, Kahl, Brad S., Byrd, John C., Wiestner, Adrian, Melnick, Ari, Parekh, Samir
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938124/
https://ncbi.nlm.nih.gov/pubmed/20427703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-257485
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