Angiopoietin-2 confers atheroprotection in apoE(-/-) mice by inhibiting LDL oxidation via nitric oxide

Atherosclerosis is promoted by a combination of hypercholesterolemia and vascular inflammation. The function of Angiopoietin-2 (Ang-2), a key regulator of angiogenesis, in the maintenance of large vessels is unknown. A single systemic administration of adenoviral Ang-2 (AdAng-2) to apoE(-/-) mice fe...

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Auteurs principaux: Ahmed, Asif, Fujisawa, Takeshi, Niu, Xi-Lin, Ahmad, Shakil, Al-Ani, Bahjat, Chudasama, Kunal, Abbas, Allyah, Potluri, Rahul, Bhandari, Vineet, Findley, Clarence M., Lam, Gregory K.W., Huang, Jianhua, Hewett, Peter, Cudmore, Melissa, Kontos, Christopher D.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938017/
https://ncbi.nlm.nih.gov/pubmed/19461044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.196154
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