HER2/ErbB2-induced Breast Cancer Cell Migration and Invasion Require p120 Catenin Activation of Rac1 and Cdc42

Breast cancers that overexpress the receptor tyrosine kinase ErbB2/HER2/Neu result in poor patient outcome because of extensive metastatic progression. Herein, we delineate a molecular mechanism that may govern this malignant phenotype. ErbB2 induction of migration requires activation of the small G...

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Autors principals: Johnson, Emhonta, Seachrist, Darcie D., DeLeon-Rodriguez, Carlos M., Lozada, Kristen L., Miedler, John, Abdul-Karim, Fadi W., Keri, Ruth A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937981/
https://ncbi.nlm.nih.gov/pubmed/20595387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136770
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